Less Than a Quarter of Those with Depression Respond to Treatment in Real Life
In a real-world setting, less than a quarter of patients diagnosed with depression improved with medication, hospitalization, and therapy.
Antidepressant-Induced Serotonin Syndrome a Danger for the Elderly
Researchers found that 25% of elderly patients taking antidepressants had serotonin syndrome, which is potentially life-threatening.
How to Distinguish Antidepressant Withdrawal from Relapse
Mark Horowitz and David Taylor provide advice on how to tell the difference between antidepressant withdrawal and depression relapse.
Did Psychiatry Ever Endorse the Chemical Imbalance Theory of Depression?
With the chemical imbalance theory falling out of fashion, researchers examine the claim that psychiatry never truly endorsed it.
Antidepressants Do Not Improve Quality of Life
A new study found that taking antidepressants did not improve quality of life.
Patient Reports Reveal SSRI Antidepressants Often Lead to Emotional Blunting
According to patient reports, SSRI antidepressants most frequently lead to the subjective experience of emotional blunting.
Official Guidelines on Antidepressant Discontinuation Fail Practitioners and Patients
A review of clinical practice guidelines for antidepressant discontinuation from across the English-speaking world reveals major pitfalls.
Shifting Away from ECT and Antidepressants for Depression
Researchers argue that we need a paradigm shift away from the biomedical model of mental illness to one informed by political action and common sense.
Negative Antidepressant Trials Still Unlikely to Be Published
Antidepressant trials with negative results are still more likely than not to either be misleadingly spun as positive or unpublished.
SSRI Antidepressants Do Not Improve Depression After a Stroke
A study in JAMA Neurology finds that antidepressants do not reduce depression symptoms more than placebo in patients recovering from a stroke.
New Review: Antidepressants Come with Minimal Benefits, Several Risks
A review of research on antidepressant efficacy finds that an unfavorable risk-to-benefit ratio.
Overuse of Psychiatric Drugs is Worsening Public Mental Health, Doctor Argues
A new research article asserts that the overuse of psychiatric drugs may create neurobiological changes that hamper long-term mental health recovery.
Researchers Push to End Placebo Run-in Periods in Antidepressant Studies
Meta-analysis finds that the placebo run-in methodology reduces the placebo effect and finds antidepressants to be less useful.
Withdrawal Symptoms Cloud Findings of Antidepressant “Relapse” Trial
Leading researchers point out that a new antidepressant study in NEJM failed to account for withdrawal symptoms, casting doubt on the results.
Giovanni Fava – A Different Psychiatry is Possible
In this podcast, we hear from the renowned clinician and researcher Dr. Giovanni Fava about his latest book entitled “Discontinuing Antidepressant Medications”.
New Rating Tool for Tapering Antidepressants and Antipsychotics
Researchers developed a rating scale to better assess service users’ experiences tapering antidepressant and/or antipsychotic medication.
Newborn Babies Go Through Antidepressant Withdrawal
A new study finds that newborn babies experience antidepressant withdrawal after birth if their mothers take SSRIs when pregnant.
“Relapse” in Antidepressant Trials Likely Caused by Sudden Withdrawal
A new study investigates how antidepressant withdrawal effects often get confounded with depression relapse in clinical trials.
Researchers Propose Study to Test Whether Antidepressants Impede Recovery
Evolutionary theorists suggest that antidepressants interfere with the adaptive function of depression and propose a test of this theory.
Four Essential Studies on Antidepressant Withdrawal Every Prescriber Must Read
A researcher and service user Stevie Lewis recounts her own experience with antidepressant withdrawal and what she wishes her doctors knew.
No, the FDA’s Black Box Warning Did not Increase Suicides
Researchers again debunk the claim that the FDA black box warnings on antidepressants led to more suicides.
Psychotherapy Can Prevent Relapse When Discontinuing Antidepressants
“Short and simple psychological programs can prevent people from relapsing when they stop their antidepressants.”
Allen Frances Takes on the Over-Prescription of Antidepressants
The prominent psychiatrist explores why antidepressants remain highly overprescribed and offers solutions to the problem.
Antidepressants Not Clinically Useful for Back Pain
While professional guidelines recommend antidepressants for back pain, researchers point out the lack of evidence for their usefulness.
Cochrane Review Calls for More Research on Antidepressant Withdrawal
Researchers find a lack of current literature on safe, effective ways to manage antidepressant withdrawal and make suggestions for future research.
