Glucose Metabolism “Derangements” from Second Generation Antipsychotics Clarified
New Zealand and Chinese investigators believe they have clarified the mechanisms by which second generation antipsychotics cause serious "derangements" in glucose metabolism in the...
Adverse Reactions to Psychiatric Medications Hospitalize 17,000 Annually
Nearly 90,000 American adults are going to emergency rooms every year in response to adverse events from psychiatric medications, according to a study in...
Antipsychotics During Pregnancy Linked to Infant Problems
“Live, healthy babies are the most common outcome following the use of antipsychotic medication in pregnancy,” conclude Australian researchers in a study that was...
20-Year Data Show Antipsychotics Do Not Reduce Psychosis
Martin Harrow's study tracing the effects of antipsychotics on 139 schizophrenia (SZ) and mood-disordered patients over 20 years, just published in Psychological Medicine, finds...
A History of Rapid Tranquilization
A paper by Joanna Moncrieff and Laura Allison in the journal History of Psychiatry reviews "the theory and practice of emergency sedation for behavioural...
Antipsychotics Ineffective Against Cocaine, Stimulant Addictions
Although cocaine and psychostimulant dependence are thought to be related to increased dopamine release, research from Tokyo and Long Island finds that the effect...
Neuroleptic Malignant Syndrome Linked to Polypharmacy, Benzos, and Race
Research from London and Taipei finds that neuroleptic malignant syndrome (NMS) is associated with the number of different antipsychotics used (polypharmacy), rather than the overall...
APA Recommends Reducing Antipsychotics for Children and Elderly Without Psychosis
The American Psychiatric Association, as part of the American Board of Internal Medicine's "Choosing Wisely" initiative, released new practice guidelines yesterday that advise against...
“Should We Stop Using Antipsychotic Medication?”
In a recent interview, Nancy Andreasen, former editor-in-chief of the American Journal of Psychiatry, reaffirmed her earlier findings that antipsychotics shrink brain tissue. "We spent a couple...
Cognitive Function Improved by Reducing Antipsychotics
A 28-week randomized controlled study by researchers in Japan, Canada and the United States finds that a 50% reduction of risperidone or olanzapine significantly...
Antipsychotics Triple the Risk of Diabetes in Children and Youth
Researchers from Vanderbilt and Columbia Universities and the FDA find that, through a retrospective cohort study of 28,858 patients of the Tennessee Medicaid program...
Reduction/Discontinuation of Antipsychotics Produces Higher Long-Term Recovery
A study published today in the American Medical Association's journal JAMA Psychiatry reports that patients whose antipsychotic treatment was reduced or discontinued (DR) experienced a recovery...
Antipsychotics and Drug Addiction
Dopamine supersensitivity as a result of sustained antipsychotic treatment can lead to compulsive drug seeking and drug-taking behavior, according to the theory offered by...
Abilify Can Worsen Psychosis & Aggression
In a systematic literature review, researchers from Canada and Japan found that the antipsychotic aripiprazole (Abilify) was significantly and causally related to increased increased...
Osteoporosis Associated with Antipsychotic Treatment
Chinese researchers find, in a literature review for the International Journal of Endocrinology find an increased rate of osteoporosis among people with a schizophrenia...
Elderly With Dementia can be Withdrawn From Antipsychotics
The Cochrane Library reports that "many older people with Alzheimer's dementia and NPS (neuropsychiatric symptoms) can be withdrawn from chronic antipsychotic medication without detrimental effects...
Antipsychotics for Poor Kids Soar, Mostly for Behavior Problems
Cross-sectional analysis by the University of Maryland and Johns Hopkins University of 456,315 youths enrolled in Medicaid between 1997 and 2006 finds that the...
Antipsychotics for Depression: Added Risk for Little Benefit
A review of research on antipsychotic medications as an adjunctive treatment for depression published this week in PLoS Medicine finds that the widespread practice...
Antipsychotics do not Result in Neurocognitive Improvement
Researchers in London and Spain, in a prospective, randomized, study of long-term (3 year) effects of first- and second-generation antipsychotics on neurocognition in 79...
Antipsychotics Associated with White-Matter Reduction
Researchers in China find an acute reduction in white matter in the frontal lobe following six weeks of antipsychotic treatment for "first-episode schizophrenia". Results...
Antipsychotics are Common for the Mechanically Ventilated
Annals of Pharmacotherapy reports in a study of patients undergoing mechanical ventilation that 39% were given antipsychotic medication to prevent or treat delirium despite...
Increasing Use of Antipsychotics for Disruptive Behavior in Children
Canadian researchers systematically reviewed all randomized controlled trials of second-generation antipsychotics (SGAs) and placebo in the treatment of disruptive behavior disorders in children, finding...
Majority of Anorexia Patients are Prescribed Psychotropics Despite Lack of Data
Research from the medical schools of Harvard University and the University of Melbourne, reported in the December International Journal of Eating Disorders, found that...
No Metabolic Risk for Antipsychotic-Naive Patients
An Austrian study of the baseline prevalence of metabolic abnormalities and changes following treatment with five commonly-used antipsychotic drugs (haloperidol, amisulpride, olanzapine, quetiapine or...
Therapy Without Drugs May Ward Off Psychosis
A double-blind, randomized, placebo-controlled study comparing outcomes from risperidone, cognitive therapy, and supportive therapy in a cohort of 115 at-risk young adults over a...
