You’ll never guess what fixes the receptors.
Prebiotics
“Besides TLR ligands, bacteria have been shown to generate and secrete large amounts of extracellular ATP. ATP is a well-known source of intracellular energy transfer; however, it also serves essential roles in extracellular signaling processes. Extracellular ATP binds and activates the cell-surface
ionotrophic (P2X) and metabotropic (P2Y) purinergic receptors, which deliver intracellular signals through ion channels or G-proteins, respectively. In the context of the immune system, extracellular ATP is known to modulate immune cell functions, such as phagocytosis,
chemotaxis, and cytokine production.”
“ATP can be quickly degraded in the extracellular space by ATPases into ADP, AMP, or adenosine forms. However,
intestinal commensal bacteria seem to produce high amounts of ATP beyond the capacity of host ATPases.”
Drug companies can be very creative. When they developed Simeprevir (for Hep C) it was insoluble so they had to formulate it to Simeprevir Sodium but there was a problem with related substance C, a toxic impurity, so the originator obtained an exemption on the normal limits to get the medicine to market.
So that’s one way of getting toxic drugs approved.
About 20-30% of the general population have gene mutations that cause low Folic Acid, Vit B12 and that increases homocysteine.
SSRIs do the same thing. They lower Folic Acid, Vit B12 and that increases homocysteine….and according to the study below, that can lead to erectile dysfunction.
Association between folic acid, homocysteine, vitamin B12 and erectile dysfunction
And according to this study, lowering the homocysteine with Folic Acid improves erectile function
Folic acid supplementation improves erectile function in patients with idiopathic vasculogenic erectile dysfunction by lowering peripheral and penile homocysteine plasma levels
I think that doctors have failed to consider that there is a pandemic of low Vitamin D, which is a neuro steroid and essential for proper brain function and works as an anti inflammatory,
2 hours of stress causes gut dysbiosis which ends up causing neuroinflammation and nothing to stop it.
Isabel,
My son knew of cases where an attempt ended up with people being quadriplegic. So he chose a lethal method. On top of his desk there was a laminated booklet that showed how to tie different kinds of knots. Although I agree that he had the right to make choices, the choice he made has caused pain to all who knew him. When someone says he did it because he was a coward I choke, with anger and sadness and pain. Recently I went to a CPR class and when the man in the video said, “respiratory distress turns into cardiac arrest” I left the room in tears. Life has become very painful now that Mark is gone.
At the suicide survivors support group the youngest victims were 10 and 13 and if they had the right to die they also had the right to live.
Please know that some of the parents who lost children are doing things to try to help.
Steve, I think you missed the part of the study that showed multiple metabolic abnormalities in the depressed group and none in controls.
Dr Pan has done several studies all showing the same thing. One study showed metabolic abnormalities in 67 out of 141. The most common were Cerebral Folate Deficiency, low tetrahydrobiopterin (which can be caused by Folate and SAMe defficiency) and were treated with Folinic Acid and Sapropterin and ALL improved and 3 were able to stop their SSRIs.
This latest study showed “Over 55% of the metabolic impact in males and 75% in females came from abnormalities in lipids.”
“Personalized deficiencies in CoQ10, flavin adenine dinucleotide (FAD), citrulline, lutein, carnitine, or folate were found.”
“Peripheral blood metabolomics identified mitochondrial dysfunction and reductive stress as common denominators in suicidal ideation associated with treatment-refractory major depressive disorder. ”
A subset, as you say, but it’s not a small subset and it’s not only in depression but it can be treated successfully.
My son didn’t have any risk factors. He never smoked, drank or used drugs. No caffeine, sodas or sweets, (he once wrote on his page that he had gone to feed the ducks and didn’t have any bread so he fed them peas). He had good sleeping habits and exercised 3-4 times per week. No financial or medical problems or childhood adversity. He was smart and kind, had many friends and plans for the future. He denied feeling suicidal and he never lied. So I looked for other causes.
1. Genetics ..I have a history of depression and MTHFR homozygous C677T mutations that cause low Folate, Vit B12 and Vit D, increase homocysteine and Histamine.
2. The Zoloft (the only drug he was taking) lowers folate and Vit D
3. Metabolic…Dr Lisa Pan did several studies that showed multiple metabolic abnormalities in treatment resistant depression and violent suicide, including Cerebral Folate Deficiency, low tetrahydrobiopterin (caused by Folate and SAMe deficiency, oxidative stress), carnitine, CoQ10, folic acid, citrulline, lutein, vitamin D and other nutrients. Plus abnormalities in purine metabolism and stress induced mitochondrial dysfunction.
There were personal differences and sex differences. Over 55% of the metabolic impact in males and 75% in females came from abnormalities in lipids. Controls had none of the abnormalities.
But now they’ll say that the metabolic abnormalities found are just a “contributing factor” to depression and might even be “the sequelae of unremitting depression” and they’ll try to sell you antipurinergic drugs.
As for MTHFR mutations….what they did is EVIL
The NIH page on drugs that cause nutrient deficiencies says SSRIs cause..
Calcium/Vitamin D decrease
Folate (3) increase (3)
The (3) means “Effect of nutrient on drug efficacy”. In other words, folate increases the efficacy of SSRIs….instead of saying SSRIs lower Folate.
Under RISK FACTORS it lists low intake and MTHFR MUTATIONS.
So they treated people who, because of genetics had low Folate and Vit D with SSRIs, antipsychotics and anticonvulsants that lower Folate and Vit D and that was a great way to increase SSRI sales.
Why is Vit D important? High rates of low Vit D in psych conditions. In Bipolar a new study showed only 5% had a level above 30. They have neuroinflammation and Vit D is a neuro steroid. Low Vitamin D increases addiction and relapse (so does low Vit B12) and suicide completers have levels below 10.
Vit D is cheap, safe and they can’t get it from the sun because it lowers Folate and the MTHFR mutation is heat sensitive and that can slow its activity.
Since low Vitamin D is associated with symptom severity and low Vitamin D during pregnancy can cause autism in the child… that covers correlation and causation.
“psychiatric disorders in limb fracture patients,”
That’s a stressor and people who have MTHFR C677T double miutations are sensitive to stress and have histamine intolerance and opioids used for pain increase histamine, and anesthesia can be dangerous. High histamine can cause depression.
“a Native American chief ”
One of the sources of MTHFR mutations
I too, ask myself how I could have been so stupid. I thank you for your post, I don’t pray but I send good thoughts your way.
You’ll never guess what fixes the receptors.
Prebiotics
“Besides TLR ligands, bacteria have been shown to generate and secrete large amounts of extracellular ATP. ATP is a well-known source of intracellular energy transfer; however, it also serves essential roles in extracellular signaling processes. Extracellular ATP binds and activates the cell-surface
ionotrophic (P2X) and metabotropic (P2Y) purinergic receptors, which deliver intracellular signals through ion channels or G-proteins, respectively. In the context of the immune system, extracellular ATP is known to modulate immune cell functions, such as phagocytosis,
chemotaxis, and cytokine production.”
“ATP can be quickly degraded in the extracellular space by ATPases into ADP, AMP, or adenosine forms. However,
intestinal commensal bacteria seem to produce high amounts of ATP beyond the capacity of host ATPases.”
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Drug companies can be very creative. When they developed Simeprevir (for Hep C) it was insoluble so they had to formulate it to Simeprevir Sodium but there was a problem with related substance C, a toxic impurity, so the originator obtained an exemption on the normal limits to get the medicine to market.
So that’s one way of getting toxic drugs approved.
Report comment
To Simon, Leonidas and others,
About 20-30% of the general population have gene mutations that cause low Folic Acid, Vit B12 and that increases homocysteine.
SSRIs do the same thing. They lower Folic Acid, Vit B12 and that increases homocysteine….and according to the study below, that can lead to erectile dysfunction.
Association between folic acid, homocysteine, vitamin B12 and erectile dysfunction
https://onlinelibrary.wiley.com/doi/10.1111/and.14234
And according to this study, lowering the homocysteine with Folic Acid improves erectile function
Folic acid supplementation improves erectile function in patients with idiopathic vasculogenic erectile dysfunction by lowering peripheral and penile homocysteine plasma levels
https://onlinelibrary.wiley.com/doi/full/10.1111/andr.12672
Obviously don’t take anything without first checking with your doctor. There’s a blood test that checks to see if you have MTHFR mutations.
Report comment
I think that doctors have failed to consider that there is a pandemic of low Vitamin D, which is a neuro steroid and essential for proper brain function and works as an anti inflammatory,
2 hours of stress causes gut dysbiosis which ends up causing neuroinflammation and nothing to stop it.
Report comment
Isabel,
My son knew of cases where an attempt ended up with people being quadriplegic. So he chose a lethal method. On top of his desk there was a laminated booklet that showed how to tie different kinds of knots. Although I agree that he had the right to make choices, the choice he made has caused pain to all who knew him. When someone says he did it because he was a coward I choke, with anger and sadness and pain. Recently I went to a CPR class and when the man in the video said, “respiratory distress turns into cardiac arrest” I left the room in tears. Life has become very painful now that Mark is gone.
At the suicide survivors support group the youngest victims were 10 and 13 and if they had the right to die they also had the right to live.
Please know that some of the parents who lost children are doing things to try to help.
Report comment
One thing is for sure, we’ve been seeing the wrong doctors. It’s like trying to cure diabetes with talk therapy.
Report comment
Steve, I think you missed the part of the study that showed multiple metabolic abnormalities in the depressed group and none in controls.
Dr Pan has done several studies all showing the same thing. One study showed metabolic abnormalities in 67 out of 141. The most common were Cerebral Folate Deficiency, low tetrahydrobiopterin (which can be caused by Folate and SAMe defficiency) and were treated with Folinic Acid and Sapropterin and ALL improved and 3 were able to stop their SSRIs.
This latest study showed “Over 55% of the metabolic impact in males and 75% in females came from abnormalities in lipids.”
“Personalized deficiencies in CoQ10, flavin adenine dinucleotide (FAD), citrulline, lutein, carnitine, or folate were found.”
“Peripheral blood metabolomics identified mitochondrial dysfunction and reductive stress as common denominators in suicidal ideation associated with treatment-refractory major depressive disorder. ”
A subset, as you say, but it’s not a small subset and it’s not only in depression but it can be treated successfully.
Report comment
My son didn’t have any risk factors. He never smoked, drank or used drugs. No caffeine, sodas or sweets, (he once wrote on his page that he had gone to feed the ducks and didn’t have any bread so he fed them peas). He had good sleeping habits and exercised 3-4 times per week. No financial or medical problems or childhood adversity. He was smart and kind, had many friends and plans for the future. He denied feeling suicidal and he never lied. So I looked for other causes.
1. Genetics ..I have a history of depression and MTHFR homozygous C677T mutations that cause low Folate, Vit B12 and Vit D, increase homocysteine and Histamine.
2. The Zoloft (the only drug he was taking) lowers folate and Vit D
3. Metabolic…Dr Lisa Pan did several studies that showed multiple metabolic abnormalities in treatment resistant depression and violent suicide, including Cerebral Folate Deficiency, low tetrahydrobiopterin (caused by Folate and SAMe deficiency, oxidative stress), carnitine, CoQ10, folic acid, citrulline, lutein, vitamin D and other nutrients. Plus abnormalities in purine metabolism and stress induced mitochondrial dysfunction.
There were personal differences and sex differences. Over 55% of the metabolic impact in males and 75% in females came from abnormalities in lipids. Controls had none of the abnormalities.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10721812/?fbclid=IwY2xjawFgHhdleHRuA2FlbQIxMQABHfrIlZETn9aSG_y6fBnld6y8tmPJyq-WWiQRLxHcM71aw9D4AT9hguyCCg_aem_LK7w0dW1uDes6qVcPkL-pw
But now they’ll say that the metabolic abnormalities found are just a “contributing factor” to depression and might even be “the sequelae of unremitting depression” and they’ll try to sell you antipurinergic drugs.
As for MTHFR mutations….what they did is EVIL
The NIH page on drugs that cause nutrient deficiencies says SSRIs cause..
Calcium/Vitamin D decrease
Folate (3) increase (3)
The (3) means “Effect of nutrient on drug efficacy”. In other words, folate increases the efficacy of SSRIs….instead of saying SSRIs lower Folate.
Under RISK FACTORS it lists low intake and MTHFR MUTATIONS.
So they treated people who, because of genetics had low Folate and Vit D with SSRIs, antipsychotics and anticonvulsants that lower Folate and Vit D and that was a great way to increase SSRI sales.
Why is Vit D important? High rates of low Vit D in psych conditions. In Bipolar a new study showed only 5% had a level above 30. They have neuroinflammation and Vit D is a neuro steroid. Low Vitamin D increases addiction and relapse (so does low Vit B12) and suicide completers have levels below 10.
Vit D is cheap, safe and they can’t get it from the sun because it lowers Folate and the MTHFR mutation is heat sensitive and that can slow its activity.
Since low Vitamin D is associated with symptom severity and low Vitamin D during pregnancy can cause autism in the child… that covers correlation and causation.
“psychiatric disorders in limb fracture patients,”
That’s a stressor and people who have MTHFR C677T double miutations are sensitive to stress and have histamine intolerance and opioids used for pain increase histamine, and anesthesia can be dangerous. High histamine can cause depression.
“a Native American chief ”
One of the sources of MTHFR mutations
I too, ask myself how I could have been so stupid. I thank you for your post, I don’t pray but I send good thoughts your way.
Report comment